2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester

Base Information

• Chemical Name: 2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester
• CAS No.: 1429043-85-5
• Molecular Formula: C₁₇H₁₅F₃N₂O₃S
• Molecular Weight: 384.379
• Mol file: 1429043-85-5.mol

Synonyms:2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester

Chemical Property of 2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester

There total 6 articles about 2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

trifluoromethylsulfonic anhydride (358-23-6) + N-benzyl-N-((E)-propenyl)-isonicotinamide (1429043-74-2) → 2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester (1429043-85-5)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/ol400571j

Reference yield: 44.0%

2,6-dimethylpyridine (108-48-5) + trifluoromethylsulfonic anhydride (358-23-6) + N-benzyl-N-((E)-propenyl)-isonicotinamide (1429043-74-2) → 2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester (1429043-85-5) + 6-methyl-2-<<<(trifluoromethyl)sulfinyl>oxy>methyl>pyridine (85371-04-6)

Guidance literature:

In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/ol400571j

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → 2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester (1429043-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.03 h / 0 °C / Inert atmosphere; Molecular sieve

2.2: 0 - 20 °C / Inert atmosphere

3.1: 2,6-di-tert-butyl-4-methylpyridine / dichloromethane / 0 °C / Inert atmosphere

With thionyl chloride; 2,6-di-tert-butyl-4-methylpyridine; triethylamine; In dichloromethane;

DOI:10.1021/ol400571j

upstream raw materials:

trifluoromethylsulfonic anhydride

N-benzyl-N-((E)-propenyl)-isonicotinamide

2,6-dimethylpyridine

pyridine-4-carboxylic acid