(3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one
CAS No.:955407-66-6
Molecular Formula:C₂₄H₂₂Cl₂FN₃O
Molecular Weight:458.363
Hs Code.:

Synonyms:(3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one

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Chemical Property of (3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one

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Technology Process of (3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one

There total 8 articles about (3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 955406-89-0
(R)-4-[3-(2,6-dichloro-4-trifluoromethanesulfonyloxy-benzyl)-2-oxo-pyrrolidin-1-yl]-4,5,6,7-tetrahydro-indazole-2-carboxylic acid tert-butyl ester

: 955406-88-9
(R)-4-[3-(2,6-dichloro-4-trifluoromethanesulfonyloxy-benzyl)-2-oxo-pyrrolidin-1-yl]-4,5,6,7-tetrahydro-indazole-1-carboxylic acid tert-butyl ester

: 1765-93-1
4-fluoroboronic acid

: 955407-66-6
(3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one

Guidance literature:: (R)-4-[3-(2,6-dichloro-4-trifluoromethanesulfonyloxy-benzyl)-2-oxo-pyrrolidin-1-yl]-4,5,6,7-tetrahydro-indazole-2-carboxylic acid tert-butyl ester; (R)-4-[3-(2,6-dichloro-4-trifluoromethanesulfonyloxy-benzyl)-2-oxo-pyrrolidin-1-yl]-4,5,6,7-tetrahydro-indazole-1-carboxylic acid tert-butyl ester; 4-fluoroboronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 80 ℃; for 1h;

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: C₂₅H₂₁Cl₂F₄N₃O₃S

: C₂₅H₂₁Cl₂F₄N₃O₃S

: 955407-66-6
(3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 955373-73-6
(R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 955407-66-6
(3R)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-1-(4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 13 h / 20 - 50 °C

2.1: hydrogen / 10 % Pd(OH)2/C / ethanol / 3 h / 20 °C / 2585.81 Torr

3.1: pyridine / dichloromethane / 0.83 h / 0 - 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 1 h / 60 - 80 °C

4.2: 20 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

With pyridine; lithium hydroxide; water; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 % Pd(OH)2/C; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane;