2-cyanoethyl-n-undecanyl fluconazole phosphate

Base Information

Chemical Name:2-cyanoethyl-n-undecanyl fluconazole phosphate
CAS No.:804566-93-6
Molecular Formula:C₂₇H₃₈F₂N₇O₄P
Molecular Weight:593.614
Hs Code.:

Synonyms:2-cyanoethyl-n-undecanyl fluconazole phosphate

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Chemical Property of 2-cyanoethyl-n-undecanyl fluconazole phosphate

Chemical Property:

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Technology Process of 2-cyanoethyl-n-undecanyl fluconazole phosphate

There total 3 articles about 2-cyanoethyl-n-undecanyl fluconazole phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 112-42-5
undecyl alcohol

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 86386-73-4
fluconazole

: 804566-93-6
2-cyanoethyl-n-undecanyl fluconazole phosphate

Guidance literature:: undecyl alcohol; 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 20h;

fluconazole; With 1H-tetrazole; In dichloromethane; for 3h;

With tert.-butylhydroperoxide; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 86386-73-4
fluconazole

: 125676-85-9
diisopropyl-phosphoramidous acid 2-cyano-ethyl ester undecyl ester

: 804566-93-6
2-cyanoethyl-n-undecanyl fluconazole phosphate

Guidance literature:: fluconazole; diisopropyl-phosphoramidous acid 2-cyano-ethyl ester undecyl ester; With 1H-tetrazole; In dichloromethane; for 3h;

With tert.-butylhydroperoxide; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/j.bmc.2004.08.049

Reference yield:

: 112-42-5
undecyl alcohol

: 804566-93-6
2-cyanoethyl-n-undecanyl fluconazole phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-diisopropylethylamine / CH₂Cl₂ / 20 h / 20 °C

2.1: 1H-tetrazole / CH₂Cl₂ / 3 h

2.2: tert-butyl hydroperoxide / CH₂Cl₂ / 1 h / 0 °C

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmc.2004.08.049