(2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol

Base Information

Chemical Name:(2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol
CAS No.:207674-25-7
Molecular Formula:C₃₈H₄₀N₄O₇
Molecular Weight:664.758
Hs Code.:

Synonyms:(2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol

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Chemical Property of (2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol

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Technology Process of (2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol

There total 4 articles about (2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 207674-04-2
2,6-Diallyloxy-9-(2',3'-dideoxy-β-D-glucopyranosyl)purin

: 207674-25-7
(2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In pyridine; for 1h; Ambient temperature;
DOI:10.1002/hlca.19980810302

Reference yield:

: 145593-73-3
(+)-[(2R,3S,6S)-2-(benzoyloxymethyl)-6-methoxyoxan-3-yl] benzoate

: 207674-25-7
(2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / N,O-bis(trimethylsilyl)acetamide, trimethylsilyl trifluoromethanesulfonate / acetonitrile / 5 h / 65 °C

2: 87 percent / Na / toluene / 4 h / 50 °C

3: 91 percent / (i-Pr)2EtN, DMAP / pyridine / 1 h / Ambient temperature

With dmap; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; sodium; N-ethyl-N,N-diisopropylamine; In pyridine; toluene; acetonitrile;
DOI:10.1002/hlca.19980810302

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 207674-25-7
(2R,3S,6R)-6-(2,6-Bis-allyloxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / N,O-bis(trimethylsilyl)acetamide, trimethylsilyl trifluoromethanesulfonate / acetonitrile / 5 h / 65 °C

2: 87 percent / Na / toluene / 4 h / 50 °C

3: 91 percent / (i-Pr)2EtN, DMAP / pyridine / 1 h / Ambient temperature

With dmap; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; sodium; N-ethyl-N,N-diisopropylamine; In pyridine; toluene; acetonitrile;
DOI:10.1002/hlca.19980810302