N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine

Base Information

Chemical Name:N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine
CAS No.:1353570-18-9
Molecular Formula:C₂₁H₂₃FN₆S
Molecular Weight:410.518
Hs Code.:
Mol file:1353570-18-9.mol

Synonyms:C₂₁H₂₃FN₆S

Suppliers and Price of N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine

Chemical Property:

Boiling Point:587.9±60.0 °C(Predicted)
PKA:5.16±0.61(Predicted)
Density:1.30±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine

There total 7 articles about N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353570-15-6
C₉H₁₆N₄S

: 2-bromo-1-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)ethanone hydrobromide

: 1353570-18-9
C₂₁H₂₃FN₆S

Guidance literature:: In ethanol; at 25 ℃; for 18.25h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2016.07.011

Reference yield:

: 118430-73-2
5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine

: 1353570-18-9
C₂₁H₂₃FN₆S

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 2 h / 60 °C / Inert atmosphere

2: potassium carbonate / methanol / 4 h / 25 °C / Inert atmosphere

3: ethanol / 18.25 h / 25 °C / Reflux; Inert atmosphere

With potassium carbonate; In methanol; ethanol; acetone;
DOI:10.1016/j.bmcl.2016.07.011

Reference yield:

: 1353570-14-5
C₁₆H₂₀N₄OS

: 1353570-18-9
C₂₁H₂₃FN₆S

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 4 h / 25 °C / Inert atmosphere

2: ethanol / 18.25 h / 25 °C / Reflux; Inert atmosphere

With potassium carbonate; In methanol; ethanol;
DOI:10.1016/j.bmcl.2016.07.011