2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&

Base Information

• Chemical Name: 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&
• CAS No.: 26907-54-0
• Molecular Formula: C9H9 N3 S
• Molecular Weight: 191.257
• Hs Code.: 2934999090
• Mol file: 26907-54-0.mol

Synonyms:1,3,4-Thiadiazole,2-amino-5-p-tolyl- (7CI,8CI)

Chemical Property of 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&

Chemical Property:

• Vapor Pressure: 1.63E-05mmHg at 25°C
• Melting Point: 218-222 °C
• Refractive Index: 1.65
• Boiling Point: 364.9°Cat760mmHg
• PKA: 3.11±0.10(Predicted)
• Flash Point: 174.5°C
• PSA: 80.04000
• Density: 1.281g/cm³
• LogP: 2.67690
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

5-(p-Tolyl)-1,3,4-thiadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI&

There total 15 articles about 2-AMINO-5-(4-METHYLPHENYL)-1 3 4-THIADI& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiosemicarbazide (79-19-6) + p-Toluic acid (99-94-5) → 2-amino-5-(4-methylphenyl)-1,3,4-thiadiazole (26907-54-0)

Guidance literature:

thiosemicarbazide; p-Toluic acid; With trichlorophosphate; at 75 ℃; for 0.5h;

With water; for 4h; Reflux;

DOI:10.1016/j.bmc.2014.09.039

Reference yield: 85.0%

4-methylbenzaldehyde thiosemicarbazone (5706-83-2) → 2-amino-5-(4-methylphenyl)-1,3,4-thiadiazole (26907-54-0)

Guidance literature:

With zinc(II) chloride hexahydrate; In ethanol; for 12h; Solvent; Reagent/catalyst; Catalytic behavior; Reflux;

DOI:10.1002/jhet.2779

Reference yield: 83.0%

trimethylsilyl isothiocyanate (2290-65-5) + p-toluic hydrazide (3619-22-5) → 2-amino-5-(4-methylphenyl)-1,3,4-thiadiazole (26907-54-0)

Guidance literature:

trimethylsilyl isothiocyanate; p-toluic hydrazide; In ethanol; Reflux;

With sulfuric acid; In ethanol; at 20 ℃;

DOI:10.1039/c3ra00159h

upstream raw materials:

4-methylbenzaldehyde thiosemicarbazone

1-(p-methylbenzoyl)-3-thisemicarbazide

C₁₁H₁₅N₃OS

thiosemicarbazide

Downstream raw materials:

N-benzoyl-N'-(5-p-tolyl-1,3,4-thiadiazol-2-yl)thiourea

2-benzoylamino-5-(p-tolyl)-1,3,4-thiadiazole

6-phenyl-2-p-tolyl-imidazo[2,1-b][1,3,4]thiadiazole

C₁₈H₁₄N₄SO