C₇₃H₁₂₂N₆O₁₁Si₄

Base Information

• Chemical Name: C₇₃H₁₂₂N₆O₁₁Si₄
• CAS No.: 320748-89-8
• Molecular Formula: C₇₃H₁₂₂N₆O₁₁Si₄
• Molecular Weight: 1372.15
• Mol file: 320748-89-8.mol

Synonyms:C₇₃H₁₂₂N₆O₁₁Si₄

Chemical Property of C₇₃H₁₂₂N₆O₁₁Si₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₃H₁₂₂N₆O₁₁Si₄

There total 31 articles about C₇₃H₁₂₂N₆O₁₁Si₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triisopropylsilyl chloride (13154-24-0) → C73H122N6O11Si4 (320748-89-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 88 percent / imidazole / tetrahydrofuran / 36 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

2.2: 83 percent / CuBr*SMe₂; BF₃*OEt₂ / tetrahydrofuran; pentane / -45 - -20 °C

3.1: imidazole / CH₂Cl₂ / 11 h / 20 °C

4.1: 289 mg / H₂ / Pd/C / ethyl acetate / 50 h / 2280.15 Torr

5.1: 84 percent / Dess-Martin periodinone / CH₂Cl₂ / 0.75 h / 0 °C

6.1: 93 percent / NaClO₂; NaH₂PO₄*H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 0 °C

7.1: diethyl cyanophosphinate; iPr₂NEt / CH₂Cl₂ / 0.33 h / -20 °C

7.2: 68 percent / CH₂Cl₂ / 2 h / -20 °C

8.1: 95 percent / H₂ / Pd/C / ethanol / 2 h / 760.05 Torr

9.1: 41 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; iPr₂NEt / CH₂Cl₂ / 21 h

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; diethylphosphoryl cyanide; 2-methyl-but-2-ene; hydrogen; tert.-butyl lithium; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; tert-butyl alcohol; pentane; 5.1: Dess-Martin oxidation;

DOI:10.1021/ol006759x

Reference yield:

4-bromo-phenol (106-41-2) → C73H122N6O11Si4 (320748-89-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 88 percent / imidazole / tetrahydrofuran / 36 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

2.2: 83 percent / CuBr*SMe₂; BF₃*OEt₂ / tetrahydrofuran; pentane / -45 - -20 °C

3.1: imidazole / CH₂Cl₂ / 11 h / 20 °C

4.1: 289 mg / H₂ / Pd/C / ethyl acetate / 50 h / 2280.15 Torr

5.1: 84 percent / Dess-Martin periodinone / CH₂Cl₂ / 0.75 h / 0 °C

6.1: 93 percent / NaClO₂; NaH₂PO₄*H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 0 °C

7.1: diethyl cyanophosphinate; iPr₂NEt / CH₂Cl₂ / 0.33 h / -20 °C

7.2: 68 percent / CH₂Cl₂ / 2 h / -20 °C

8.1: 95 percent / H₂ / Pd/C / ethanol / 2 h / 760.05 Torr

9.1: 41 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; iPr₂NEt / CH₂Cl₂ / 21 h

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; diethylphosphoryl cyanide; 2-methyl-but-2-ene; hydrogen; tert.-butyl lithium; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; tert-butyl alcohol; pentane; 5.1: Dess-Martin oxidation;

DOI:10.1021/ol006759x

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → C73H122N6O11Si4 (320748-89-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 81 percent / imidazole / CH₂Cl₂ / 9 h

2: 86 percent / DMAP; K₂CO₃ / dimethylformamide / 21 h

3: 88 percent / Bu₃SnH; AcOH / Pd(PPh₃)4 / CH₂Cl₂ / 1 h / 0 °C

4: 319 mg / iPr₂NEt₃; FDPP / CH₂Cl₂ / 48 h

5: Bu₃SnH; AcOH / Pd(PPh₃)4 / CH₂Cl₂ / 0.5 h / 0 °C

6: 41 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; iPr₂NEt / CH₂Cl₂ / 21 h

With 1H-imidazole; dmap; iPr₂NEt₃; pentafluorophenyl diphenyl-phosphinate; tri-n-butyl-tin hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol006759x

upstream raw materials:

(R)-2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-3-(4-triisopropylsilanyloxy-phenyl)-propionylamino]-4-methyl-pentanoic acid

4-bromo-phenol

triisopropylsilyl chloride

t-butyldimethylsiyl triflate