(E)-2-<(9R)-7-formyl-9-<(3Z)-3-hexene-1,5-diynyl>-6-phthalimido-9-<(triethylsilyl)oxy>-1,4-dioxaspiro<4,5>dec-6-en-8-ylidene>acetic acid, methyl ester

Base Information

Chemical Name:(E)-2-<(9R)-7-formyl-9-<(3Z)-3-hexene-1,5-diynyl>-6-phthalimido-9-<(triethylsilyl)oxy>-1,4-dioxaspiro<4,5>dec-6-en-8-ylidene>acetic acid, methyl ester
CAS No.:139609-39-5
Molecular Formula:C₃₂H₃₃NO₈Si
Molecular Weight:587.701
Hs Code.:

Synonyms:(E)-2-<(9R)-7-formyl-9-<(3Z)-3-hexene-1,5-diynyl>-6-phthalimido-9-<(triethylsilyl)oxy>-1,4-dioxaspiro<4,5>dec-6-en-8-ylidene>acetic acid, methyl ester

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Chemical Property of (E)-2-<(9R)-7-formyl-9-<(3Z)-3-hexene-1,5-diynyl>-6-phthalimido-9-<(triethylsilyl)oxy>-1,4-dioxaspiro<4,5>dec-6-en-8-ylidene>acetic acid, methyl ester

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Technology Process of (E)-2-<(9R)-7-formyl-9-<(3Z)-3-hexene-1,5-diynyl>-6-phthalimido-9-<(triethylsilyl)oxy>-1,4-dioxaspiro<4,5>dec-6-en-8-ylidene>acetic acid, methyl ester

There total 1 articles about (E)-2-<(9R)-7-formyl-9-<(3Z)-3-hexene-1,5-diynyl>-6-phthalimido-9-<(triethylsilyl)oxy>-1,4-dioxaspiro<4,5>dec-6-en-8-ylidene>acetic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139609-38-4
C₃₂H₃₃NO₈Si

: 139609-39-5
(E)-2-<(9R)-7-formyl-9-<(3Z)-3-hexene-1,5-diynyl>-6-phthalimido-9-<(triethylsilyl)oxy>-1,4-dioxaspiro<4,5>dec-6-en-8-ylidene>acetic acid, methyl ester

: 150053-12-6
N-{(R)-7-Formyl-9-((Z)-hex-3-ene-1,5-diynyl)-8-[1-methoxycarbonyl-meth-(E)-ylidene]-9-triethylsilanyloxy-1,4-dioxa-spiro[4.5]dec-6-en-6-yl}-phthalamic acid

Guidance literature:: With silica gel; In dichloromethane; at 20 ℃; for 2h; Yields of byproduct given;

Reference yield:

: 139609-39-5
(E)-2-<(9R)-7-formyl-9-<(3Z)-3-hexene-1,5-diynyl>-6-phthalimido-9-<(triethylsilyl)oxy>-1,4-dioxaspiro<4,5>dec-6-en-8-ylidene>acetic acid, methyl ester

: 144668-33-7
(2E)-2-{(1R,4Z,8S)-8-hydroxy-10-[(methoxycarbonyl)amino]-1-[(triethylsilyl)oxy]-13H-spiro[bicyclo[7.3.1]trideca-4,9-diene-2,6-diyne-11,2'-[1,3]dioxolan]-13-ylidene}ethyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: methylhydrazine / benzene / 0.5 h / 25 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

4.1: cerium(III) chloride heptahydrate / methanol / 0.33 h / 25 °C / Inert atmosphere

4.2: 1 h / 25 °C / Inert atmosphere

5.1: pyridine / dichloromethane / 1 h / -15 °C / Inert atmosphere

With pyridine; cerium(III) chloride heptahydrate; methylhydrazine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; benzene; 4.1: |Luche Cerium Reduction / 4.2: |Luche Cerium Reduction;
DOI:10.1021/jacs.8b06955