1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide

Base Information

Chemical Name:1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide
CAS No.:1566543-27-8
Molecular Formula:C₂₉H₃₂F₃N₅O
Molecular Weight:523.601
Hs Code.:

Synonyms:1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide

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Chemical Property of 1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide

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Technology Process of 1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide

There total 12 articles about 1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1566544-23-7
tert-butyl 4-(4-((4-(2-(1-carbamoylcyclobutyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

: 1566543-27-8
1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: 1566544-18-0
tert-butyl 4-(4-((4-ethynyl-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

: 1566543-27-8
1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.17 h

1.2: 0.33 h / 120 °C / Microwave irradiation

2.1: hydrogen; palladium 10% on activated carbon; triethylamine / ethyl acetate

3.1: lithium hydroxide / tetrahydrofuran; water / 288 h / 40 °C / Reflux

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonium carbonate; triethylamine / N,N-dimethyl-formamide / 40 °C

5.1: dichloromethane / 20 °C

With ammonium carbonate; copper(l) iodide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1566544-19-1
methyl 1-(2-iodophenyl)cyclobutanecarboxylate

: 1566543-27-8
1-(2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.17 h

1.2: 0.33 h / 120 °C / Microwave irradiation

2.1: hydrogen; palladium 10% on activated carbon; triethylamine / ethyl acetate

3.1: lithium hydroxide / tetrahydrofuran; water / 288 h / 40 °C / Reflux

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonium carbonate; triethylamine / N,N-dimethyl-formamide / 40 °C

5.1: dichloromethane / 20 °C

With ammonium carbonate; copper(l) iodide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;