5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Base Information

Chemical Name:5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine
CAS No.:1239479-92-5
Molecular Formula:C₁₉H₂₃N₅O
Molecular Weight:337.425
Hs Code.:

Synonyms:5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

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Chemical Property of 5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

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Technology Process of 5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

There total 5 articles about 5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 110-85-0
piperazine

: 898533-77-2
2-[4-(2-bromoethoxy)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyridine

: 1239479-92-5
5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: In chloroform; at 20 ℃;
DOI:10.2174/157017811795038377

Reference yield: 55.7%

: 39996-42-4
1-amino-2-methylpyridinium mesitylenesulfonate

: 351343-88-9
4-(2-(piperazin-1-yl)ethoxy)benzonitrile

: 1239479-92-5
5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 24h; Cooling with ice;
DOI:10.2174/157340610791321505

Reference yield:

: 937690-98-7
C₁₃H₁₈N₂O₂

: 1239479-92-5
5-methyl-2-[4-(2-piperazin-1-ylethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; oxygen; copper; ammonium chloride / 24 h / 60 °C

2: potassium hydroxide / ethanol / 24 h / 20 °C / Cooling with ice

With pyridine; oxygen; copper; ammonium chloride; potassium hydroxide; In ethanol;
DOI:10.2174/157340610791321505