(2S,3R,4R)-2-amino-4-hydroxy-3-methylpentanoic acid

Base Information

Chemical Name:(2S,3R,4R)-2-amino-4-hydroxy-3-methylpentanoic acid
CAS No.:21704-86-9
Molecular Formula:C₆H₁₃NO₃
Molecular Weight:147.174
Hs Code.:
European Community (EC) Number:672-526-4
Nikkaji Number:J35.791J
Wikidata:Q105198775
Mol file:21704-86-9.mol

Synonyms:4-hydroxyisoleucine

Suppliers and Price of (2S,3R,4R)-2-amino-4-hydroxy-3-methylpentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 17 raw suppliers

Chemical Property of (2S,3R,4R)-2-amino-4-hydroxy-3-methylpentanoic acid

Chemical Property:

Vapor Pressure:1.11E-05mmHg at 25°C
Melting Point:>200°C
Refractive Index:1.495
Boiling Point:332°C
Flash Point:147°C
PSA：83.55000
Density:1.181
LogP:0.11550
XLogP3:-2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:147.08954328
Heavy Atom Count:10
Complexity:126

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C)O)C(C(=O)O)N
Isomeric SMILES:C[C@@H]([C@@H](C)O)[C@@H](C(=O)O)N
Uses Used as a treatment for type II diabetes

Technology Process of (2S,3R,4R)-2-amino-4-hydroxy-3-methylpentanoic acid

There total 68 articles about (2S,3R,4R)-2-amino-4-hydroxy-3-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 55527-86-1,168610-73-9,681230-42-2,695148-12-0,697797-11-8
(3S,4R,5S)-3-amino-4,5-dimethyldihydrofuran-2(3H)-one

: 55527-85-0,168610-73-9,681230-42-2,695148-12-0,697797-11-8
(3S,4R,5R)-3-Amino-4,5-dimethyl-dihydro-furan-2-one

: 55399-93-4,21704-86-9
(2S,3R,4S)-4-hydroxyisoleucine

Guidance literature:: (3S,4R,5S)-3-amino-4,5-dimethyldihydrofuran-2(3H)-one; (3S,4R,5R)-3-Amino-4,5-dimethyl-dihydro-furan-2-one; With lithium hydroxide; water; at 20 ℃; for 2h;

With acetic acid;

Reference yield: 84.2%

: 73-32-5,959215-79-3,18875-42-8
L-isoleucine

: 55399-93-4,21704-86-9
(2S,3R,4S)-4-hydroxyisoleucine

Guidance literature:: With oxygen; α-ketoglutarate; iron(II) sulfate; sodium hydroxide; In aq. phosphate buffer; at 30 ℃; for 72h; pH=7; Temperature; pH-value; Reagent/catalyst; stereoselective reaction; Catalytic behavior; Green chemistry; Enzymatic reaction;
DOI:10.1021/acs.jafc.0c06544