1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione

Base Information

Chemical Name:1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione
CAS No.:1456900-79-0
Molecular Formula:C₂₉H₃₆N₂O₅
Molecular Weight:492.615
Hs Code.:

Synonyms:1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione

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Chemical Property of 1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione

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Technology Process of 1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione

There total 9 articles about 1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₈N₂O₅

: 1456900-79-0
1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione

Guidance literature:: C₂₉H₃₈N₂O₅; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - -10 ℃; for 4h; Inert atmosphere;
DOI:10.1007/s00726-013-1571-4

Reference yield:

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
(S)-1-(4-methoxyphenyl)ethylamine

: 1456900-79-0
1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / dichloromethane / 12 h / 0 °C

1.2: 48 h

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

2.2: 10 h / -78 °C

3.1: acetic acid / tetrahydrofuran; water / 10 h / 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

4.2: Swern Oxidation / 4 h / -78 - -10 °C / Inert atmosphere

With oxalyl dichloride; acetic acid; dimethyl sulfoxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; 4.1: |Swern Oxidation;
DOI:10.1007/s00726-013-1571-4

Reference yield:

: 1141931-86-3
1,4-bis[(S)-1-(4-methoxyphenyl)ethyl]piperazine-2,5-dione

: 1456900-79-0
1,4-bis((S)-1-(4-methoxyphenyl)ethyl)-3-((4-oxocyclohexyl)methyl)piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

1.2: 10 h / -78 °C

2.1: acetic acid / tetrahydrofuran; water / 10 h / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

3.2: Swern Oxidation / 4 h / -78 - -10 °C / Inert atmosphere

With oxalyl dichloride; acetic acid; dimethyl sulfoxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; 3.1: |Swern Oxidation;
DOI:10.1007/s00726-013-1571-4