3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-propan-1-ol

Base Information

• Chemical Name: 3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-propan-1-ol
• CAS No.: 197862-43-4
• Molecular Formula: C₁₃H₁₆O₃S₂
• Molecular Weight: 284.4
• Mol file: 197862-43-4.mol

Synonyms:3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-propan-1-ol

Chemical Property of 3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-propan-1-ol

There total 1 articles about 3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Allyl-4-phenylsulfanyl-2,5-dihydro-thiophene 1,1-dioxide (110026-88-5) → 3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ6-thiophen-2-yl)-propan-1-ol (197862-43-4)

Guidance literature:

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; Yield given. Multistep reaction; 1.) THF, from 0 deg C to RT, 2.) THF, from 0 deg C to RT;

DOI:10.1002/jccs.199700055

Reference yield: 80.0%

3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ6-thiophen-2-yl)-propan-1-ol (197862-43-4) → 3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ6-thiophen-2-yl)-propionaldehyde (197862-45-6)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1002/jccs.199700055

Reference yield:

3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ6-thiophen-2-yl)-propan-1-ol (197862-43-4) → 5-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ6-thiophen-2-yl)-pent-1-en-3-one (197862-49-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

2: 60 percent / pyridinium chlorochromate / tetrahydrofuran / 0.25 h / 0 °C

3: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Heating

With pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jccs.199700055

upstream raw materials:

2-Allyl-4-phenylsulfanyl-2,5-dihydro-thiophene 1,1-dioxide

Downstream raw materials:

3-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-propionaldehyde

5-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-pent-1-en-3-one

5-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-pent-1-en-3-ol