N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide

Base Information

Chemical Name:N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide
CAS No.:213984-35-1
Molecular Formula:C₃₀H₂₄F₃NO₄
Molecular Weight:519.52
Hs Code.:

Synonyms:N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide

There total 5 articles about N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2150-43-8
3,4-dihydroxybenzoic acid methyl ester

: 213984-35-1
N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 0.17 h / 170 - 180 °C

2: 1.26 g / LiAlH₄ / diethyl ether / 1.5 h / Ambient temperature

3: MnO₂

4: 2.) NaBH₄ / 1.) MeOH, reflux, 3 h, 2.) MeOH, 0 deg C, 30 min

5: pyridine / 1.5 h / 0 °C

With manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; In pyridine; diethyl ether;
DOI:10.1021/jo9807868

Reference yield:

: 150191-66-5
2,2-diphenylbenzo[d][1,3]dioxole-5-carbaldehyde

: 213984-35-1
N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NaBH₄ / 1.) MeOH, reflux, 3 h, 2.) MeOH, 0 deg C, 30 min

2: pyridine / 1.5 h / 0 °C

With sodium tetrahydroborate; In pyridine;
DOI:10.1021/jo9807868

Reference yield:

: 70006-59-6
2,2-Diphenyl-1,3-benzodioxol-5-methanol

: 213984-35-1
N-(2,2-Diphenyl-benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: MnO₂

2: 2.) NaBH₄ / 1.) MeOH, reflux, 3 h, 2.) MeOH, 0 deg C, 30 min

3: pyridine / 1.5 h / 0 °C

With manganese(IV) oxide; sodium tetrahydroborate; In pyridine;
DOI:10.1021/jo9807868