phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol

Base Information

Chemical Name:phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol
CAS No.:1600566-40-2
Molecular Formula:C₂₉H₁₈F₆N₂O
Molecular Weight:524.465
Hs Code.:

Synonyms:phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol

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Chemical Property of phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol

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Technology Process of phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol

There total 4 articles about phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5424-19-1
3-Benzoylpyridine

: 1600562-92-2
6-bromo-3-phenyl-2,4-bis(trifluoromethyl)quinoline

: 1600566-40-2
phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol

Guidance literature:: 3-Benzoylpyridine; 6-bromo-3-phenyl-2,4-bis(trifluoromethyl)quinoline; With n-butyllithium; In tetrahydrofuran; at -70 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; ethyl acetate; Inert atmosphere;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1600566-40-2
phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.1 h / -68 °C / Inert atmosphere; Cooling with acetone-dry ice

1.2: Inert atmosphere

2.1: sodium azide / dimethyl sulfoxide / 1 h / 95 °C

2.2: 0.5 h / 20 °C

3.1: tributyl-amine / N,N-dimethyl-formamide / 2 h / 130 °C

4.1: n-butyllithium / tetrahydrofuran / -70 °C / Inert atmosphere

4.2: Inert atmosphere

With n-butyllithium; sodium azide; tributyl-amine; diisopropylamine; In tetrahydrofuran; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 617706-15-7
1-(5-bromo-2-fluorophenyl)-2,2,2-trifluoro-ethanone

: 1600566-40-2
phenyl(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / dimethyl sulfoxide / 1 h / 95 °C

1.2: 0.5 h / 20 °C

2.1: tributyl-amine / N,N-dimethyl-formamide / 2 h / 130 °C

3.1: n-butyllithium / tetrahydrofuran / -70 °C / Inert atmosphere

3.2: Inert atmosphere

With n-butyllithium; sodium azide; tributyl-amine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;