[3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4_,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine

Base Information

• Chemical Name: [3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4_,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine
• CAS No.: 1448692-77-0
• Molecular Formula: C₂₀H₁₆N₈O
• Molecular Weight: 384.4

Synonyms:[3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4_,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine

Chemical Property of [3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4_,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine

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Technology Process of [3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4_,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine

There total 4 articles about [3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4_,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N4-(4-methoxy-phenyl)-N2-(1-phenyl-1H-pyrazol-4-yl)-pyrimidine-2,4,5-triamine (1448694-36-7) → [3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine (1448692-77-0)

Guidance literature:

With sulfuric acid; water; sodium nitrite; at 20 ℃; for 16h;

Reference yield:

(2-chloro-5-nitro-pyrimidin-4-yl)-(4-methoxy-phenyl)-amine (1331961-87-5) → [3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine (1448692-77-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 20 °C

2: hydrogen; palladium on activated charcoal / tetrahydrofuran / 20 °C / 760.05 Torr

3: sodium nitrite; sulfuric acid; water / 16 h / 20 °C

With sulfuric acid; palladium on activated charcoal; water; hydrogen; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

N4-(4-methoxy-phenyl)-5-nitro-N2-(1-phenyl-1H-pyrazol-4-yl)-pyrimidine-2,4-diamine (1448694-35-6) → [3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]-(1-phenyl-1H-pyrazol-4-yl)-amine (1448692-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / tetrahydrofuran / 20 °C / 760.05 Torr

2: sodium nitrite; sulfuric acid; water / 16 h / 20 °C

With sulfuric acid; palladium on activated charcoal; water; hydrogen; sodium nitrite; In tetrahydrofuran;

upstream raw materials:

2-methoxy-phenylamine

(2-chloro-5-nitro-pyrimidin-4-yl)-(4-methoxy-phenyl)-amine

N⁴-(4-methoxy-phenyl)-5-nitro-N²-(1-phenyl-1H-pyrazol-4-yl)-pyrimidine-2,4-diamine

N⁴-(4-methoxy-phenyl)-N²-(1-phenyl-1H-pyrazol-4-yl)-pyrimidine-2,4,5-triamine

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