(S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

• Chemical Name: (S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
• CAS No.: 1245370-39-1
• Molecular Formula: C₄₁H₇₀N₆O₁₁
• Molecular Weight: 823.04
• Mol file: 1245370-39-1.mol

Synonyms:(S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Chemical Property of (S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 1 articles about (S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(2-(2-(2-(2-chloroacetamido)ethoxy)ethoxy)ethyl)-4-hydroxybenzamide (1245370-35-7) + 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) → (S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1245370-39-1)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 - 90 ℃; Inert atmosphere;

DOI:10.1021/jm100289b

Reference yield: 97.0%

(S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1245370-39-1) → (S)-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid (1245370-40-4)

Guidance literature:

With trifluoroacetic acid; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm100289b

Reference yield: 90.0%

(S)-tert-butyl-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1245370-39-1) + N-[4-nitro-3-(trifluoromethyl)phenyl]-(2R)-3-bromo-2-hydroxy-2-methylpropanamide (206193-18-2) → (S)-tert-butyl-2,2',2-(10-(1-(4-(2-hydroxy-2-methyl-3-(4-nitro-3-(trifluoromethyl)phenylamino)-3-oxopropoxy)phenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1245370-28-8)

Guidance literature:

With potassium carbonate; In butanone; at 20 - 80 ℃; Inert atmosphere;

DOI:10.1021/jm100289b

upstream raw materials:

N-(2-(2-(2-(2-chloroacetamido)ethoxy)ethoxy)ethyl)-4-hydroxybenzamide

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

Downstream raw materials:

(S)-2,2',2-(10-(1-(4-hydroxyphenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

(S)-tert-butyl-2,2',2-(10-(1-(4-(2-hydroxy-2-methyl-3-(4-nitro-3-(trifluoromethyl)phenylamino)-3-oxopropoxy)phenyl)-1,12-dioxo-5,8-dioxa-2,11-diazatridecan-13-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate