2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline

Base Information

Chemical Name:2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline
CAS No.:1377966-42-1
Molecular Formula:C₂₂H₂₁ClN₂O₇
Molecular Weight:460.871
Hs Code.:

Synonyms:2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline

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Chemical Property of 2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline

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Technology Process of 2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline

There total 4 articles about 2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1377966-41-0
2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-1-oxo-1,2-dihydroisoquinoline

: 1377966-42-1
2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline

Guidance literature:: With nitric acid; acetic acid; In ethyl acetate; at 10 ℃; for 2h;
DOI:10.1021/jo3006039

Reference yield:

: 1377966-35-2
methyl 2-[(3-chloropropylimino)methyl]benzoate

: 1377966-42-1
2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: chloroform / 3 h / 20 °C

2: 1-methyl-pyrrolidin-2-one / 170 - 190 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 7 h / Reflux

4: nitric acid; acetic acid / ethyl acetate / 2 h / 10 °C

With nitric acid; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; chloroform; ethyl acetate;
DOI:10.1021/jo3006039

Reference yield:

: cis-4-carboxy-2-(3-chloropropyl)-6,7-dimethoxy-3-(2-(methoxycarbonyl)phenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline

: 1377966-42-1
2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 170 - 190 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 7 h / Reflux

3: nitric acid; acetic acid / ethyl acetate / 2 h / 10 °C

With nitric acid; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethyl acetate;
DOI:10.1021/jo3006039