2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol

Base Information

Chemical Name:2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol
CAS No.:678196-17-3
Molecular Formula:C₁₃H₁₇NO
Molecular Weight:203.284
Hs Code.:

Synonyms:2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol

Suppliers and Price of 2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol

There total 11 articles about 2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 678196-16-2
2-[1-(4-methylphenylsulfonyl)-(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethyl acetate

: 678196-17-3
2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; for 6h; Heating;
DOI:10.1016/j.tet.2004.04.019

Reference yield:

: 51985-30-9,137845-37-5,144381-72-6
4-Methyl-N-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-benzenesulfonamide

: 678196-17-3
2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 0.33 h / -78 °C

1.2: 61 percent / tetrahydrofuran / 0.33 h / -78 °C

2.1: 84 percent / N-bromosuccinimide; water / toluene; CHCl₃ / 1 h / 20 °C

3.1: 76 percent / tri-n-butyltin hydride; AIBN / benzene / 1.5 h / Heating

4.1: 96 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

5.1: 90 percent / K₂CO₃ / acetonitrile / 2 h / Heating

6.1: triethylamine / acetonitrile / 0.83 h / 0 °C

7.1: NaHCO₃ / acetonitrile; H₂O / 0.33 h / 0 °C

8.1: 449 mg / benzene / 0.5 h / 20 °C

9.1: 80 percent / bis(tricyclohexylphosphine)benzylideneruthenium dichloride / toluene / 16 h / Heating

10.1: 78 percent / Ha-Hg; Na₂HPO₄ / methanol / 6 h / Heating

With pyridine; disodium hydrogenphosphate; sodium amalgam; N-Bromosuccinimide; Grubbs catalyst first generation; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; toluene; acetonitrile; benzene; 6.1: Pummerer reaction;
DOI:10.1016/j.tet.2004.04.019

Reference yield:

: 678196-02-6
4-methyl-1-[2-(S_R)(4-methylphenylsulfonamido)-4-phenyl-(2R,3E)-3-butenylsulfinyl]benzene

: 678196-17-3
2-[(2R)-1,2,5,6-tetrahydropyridin-2-yl]-1-phenyl-(1R)-ethan-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 84 percent / N-bromosuccinimide; water / toluene; CHCl₃ / 1 h / 20 °C

2: 76 percent / tri-n-butyltin hydride; AIBN / benzene / 1.5 h / Heating

3: 96 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

4: 90 percent / K₂CO₃ / acetonitrile / 2 h / Heating

5: triethylamine / acetonitrile / 0.83 h / 0 °C

6: NaHCO₃ / acetonitrile; H₂O / 0.33 h / 0 °C

7: 449 mg / benzene / 0.5 h / 20 °C

8: 80 percent / bis(tricyclohexylphosphine)benzylideneruthenium dichloride / toluene / 16 h / Heating

9: 78 percent / Ha-Hg; Na₂HPO₄ / methanol / 6 h / Heating

With pyridine; disodium hydrogenphosphate; sodium amalgam; N-Bromosuccinimide; Grubbs catalyst first generation; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; In methanol; dichloromethane; chloroform; water; toluene; acetonitrile; benzene; 5: Pummerer reaction;
DOI:10.1016/j.tet.2004.04.019