Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat

Base Information

• Chemical Name: Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat
• CAS No.: 73870-16-3
• Molecular Formula: C₂₃H₂₇NO₈
• Molecular Weight: 445.469
• Mol file: 73870-16-3.mol

Synonyms:Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat

Chemical Property of Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat

There total 3 articles about Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

lead(IV) tetraacetate (546-67-8) + Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-methylpyrrol-3-propionat (73870-06-1) → Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat (73870-16-3)

Guidance literature:

With acetic anhydride; In acetic acid; Ambient temperature;

Reference yield:

3-(2-ethoxycarbonylethyl)-4-formyl-5-methylpyrrole-2-carboxylate (58950-57-5) → Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat (73870-16-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.6 g / pyridine, piperidine / 11 h / 90 °C

2: 240 mg / H₂ / palladium-on-charcoal (10percent) / ethanol

3: 2.1 g / sodium / 3 h / 100 - 110 °C

4: acetic acid / 7 h / Ambient temperature

With piperidine; pyridine; hydrogen; sodium; palladium on activated charcoal; In ethanol; acetic acid;

DOI:10.1071/CH9831639

Reference yield:

ethyl 3,4-di(2-ethoxycarbonylethyl)-5-methylpyrrole-2-carboxylate (88865-63-8) → Methyl-2-acetoxymethyl-5-benzyloxycarbonyl-4-methoxycarbonylethylpyrrol-3-propionat (73870-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.1 g / sodium / 3 h / 100 - 110 °C

2: acetic acid / 7 h / Ambient temperature

With sodium; In acetic acid;

DOI:10.1071/CH9831639

upstream raw materials:

lead(IV) tetraacetate

Methyl-5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-2-methylpyrrol-3-propionat

3-(2-ethoxycarbonylethyl)-4-formyl-5-methylpyrrole-2-carboxylate

ethyl 3,4-di(2-ethoxycarbonylethyl)-5-methylpyrrole-2-carboxylate