Alanine, N-hydroxy-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Alanine, N-hydroxy-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 21653-09-8
• Molecular Formula: C₇H₁₅NO₃
• Molecular Weight: 161.201
• Mol file: 21653-09-8.mol

Synonyms:Alanine,N-hydroxy-, tert-butyl ester, DL- (8CI); DL-Alanine, N-hydroxy-,1,1-dimethylethyl ester; tert-Butyl 2-(hydroxyamino)propionate

Chemical Property of Alanine, N-hydroxy-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Melting Point: 73-74 °C
• Boiling Point: 234.1±42.0 °C(Predicted)
• PKA: 11.91±0.50(Predicted)
• PSA: 58.56000
• Density: 1.044±0.06 g/cm3(Predicted)
• LogP: 1.08630

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Alanine, N-hydroxy-, 1,1-dimethylethyl ester (9CI)

There total 5 articles about Alanine, N-hydroxy-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-benzylidenealanine N-oxide tert-butyl ester (58581-46-7) → N-hydroxy-DL-alanine t-butyl ester (21653-09-8,83451-16-5,57001-44-2)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; at 40 ℃;

DOI:10.1139/v03-123

Reference yield:

sulfuric acid (7664-93-9) + 2-Bromopropionic acid (598-72-1,10327-08-9) + isobutene (115-11-7,15220-85-6) → N-hydroxy-DL-alanine t-butyl ester (21653-09-8,83451-16-5,57001-44-2)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; sodium methylate; triethylamine; In methanol; Petroleum ether;

Reference yield:

tert-butyl 2-bromopropionate (39149-80-9,54631-38-8,98104-35-9,32821-07-1) → N-hydroxy-DL-alanine t-butyl ester (21653-09-8,83451-16-5,57001-44-2)

Guidance literature:

With hydroxylamine; triethylamine; In methanol; Heating;

DOI:10.1246/bcsj.47.3109

upstream raw materials:

tert-butyl 2-bromopropionate

C₁₄H₁₉NO₃

N-benzylidenealanine N-oxide tert-butyl ester

sulfuric acid

Downstream raw materials:

N-(α-Ethoxy-cinnamoyl)-N-hydroxy-DL-alanin-tert.-butylester

N-(2-acetoxy-3-phenyl-acryloyl)-N-hydroxy-DL-alanine tert-butyl ester

O-(benzyloxycarbonylglycyl)-N-hydroxy-DL-alanine t-butyl ester