N-Acetyl-alpha-neuraminic acid

Base Information

Chemical Name:N-Acetyl-alpha-neuraminic acid
CAS No.:21646-00-4
Molecular Formula:C₁₁H₁₉NO₉
Molecular Weight:309.273
Hs Code.:
European Community (EC) Number:205-023-1
UNII:04A90EXP8V
DSSTox Substance ID:DTXSID201309514
Nikkaji Number:J614.853K
Wikipedia:N-Acetylneuraminic_acid
Wikidata:Q310828
Metabolomics Workbench ID:37419
ChEMBL ID:CHEMBL1234621

Synonyms:Mulkine

Suppliers and Price of N-Acetyl-alpha-neuraminic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-Acetyl-alpha-neuraminic acid

Chemical Property:

Boiling Point:805°Cat760mmHg
PKA:2.31±0.70(Predicted)
Flash Point:440.7°C
PSA：176.78000
Density:1.64g/cm³
LogP:-3.48090
XLogP3:-3.5
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:309.10598118
Heavy Atom Count:21
Complexity:403

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Chemical Classes:Biological Agents -> Monosaccharides and Derivatives
Canonical SMILES:CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O
Isomeric SMILES:CC(=O)N[C@@H]1[C@H](C[C@@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)O)O)O
Recent EU Clinical Trials:A Phase 2 Open-label study to Evaluate the Safety of Aceneuramic Acid Extended

Technology Process of N-Acetyl-alpha-neuraminic acid

There total 19 articles about N-Acetyl-alpha-neuraminic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 300595-03-3
N-[(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosyl)onate]-3',4'-dimethylpyridinium

: 583-58-4
3,4-Lutidin

: 6813-81-6,14120-72-0,19342-33-7,21646-00-4,82349-00-6,99395-98-9,99395-99-0,99396-00-6,102734-10-1,489-46-3,140671-47-2,140850-42-6,140850-43-7,140850-44-8,145375-13-9
N-acetyl neuraminic acid

Guidance literature:: With influenza viral α-sialidase (A/Tokyo/3/67); at 37 ℃; pH=6.0; Further Variations:; pH-values; Enzyme kinetics;
DOI:10.1021/ja001641x

Reference yield:

: (2S,4S,5R,6R)-5-Acetylamino-4-hydroxy-2-(3-nitro-phenoxy)-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid

: 489-46-3,6813-81-6,14120-72-0,19342-33-7,21646-00-4,82349-00-6,99395-98-9,99395-99-0,99396-00-6,102734-10-1,140671-47-2,140850-42-6,140850-43-7,140850-44-8,145375-13-9
sialic acid

: 554-84-7
meta-nitrophenol

Guidance literature:: With sodium perchlorate; water; at 50 ℃; Rate constant; ionic strength 0.300 M; var. pH and temp.;
DOI:10.1021/ja00052a011

Reference yield:

: 3063-71-6
cytidine-5'-monophosphono-N-acetylneuraminic acid

: 6813-81-6,14120-72-0,19342-33-7,21646-00-4,82349-00-6,99395-98-9,99395-99-0,99396-00-6,102734-10-1,489-46-3,140671-47-2,140850-42-6,140850-43-7,140850-44-8,145375-13-9
N-acetyl neuraminic acid

: 489-46-3,6813-81-6,14120-72-0,19342-33-7,21646-00-4,82349-00-6,99395-98-9,99395-99-0,99396-00-6,102734-10-1,140671-47-2,140850-42-6,140850-43-7,140850-44-8,145375-13-9
sialic acid

: 63-37-6,30811-80-4
cytidine monophosphate

: 202343-12-2
(2S,4S,5R,6R)-5-Acetylamino-2-azido-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid

: 202343-12-2
(2R,4S,5R,6R)-5-Acetylamino-2-azido-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid

Guidance literature:: With sodium azide; acetate buffer; at 37 ℃; Rate constant; Product distribution; Mechanism; also in D₂O and in absence of azide; also in the presence of MeOH; solvent deuterium kinetic isotope effect;
DOI:10.1021/ja972503j