SGT₁₄₁₆

Base Information

• Chemical Name: SGT₁₄₁₆
• CAS No.: 7643-96-1
• Molecular Formula: C₁₀H₁₂FNO
• Molecular Weight: 181.21
• Mol file: 7643-96-1.mol

Synonyms:SGT₁₄₁₆

Chemical Property of SGT₁₄₁₆

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of SGT₁₄₁₆

There total 2 articles about SGT₁₄₁₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-[4-(4-fluoro-phenyl)-4-oxo-butyl]-phthalimide (7347-72-0) → SGT1416 (7643-96-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Heating;

DOI:10.1021/jm00069a010

Reference yield:

C10H10FN3O (154440-76-3) → SGT1416 (7643-96-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 8h; under 750.075 Torr;

DOI:10.1021/acs.jmedchem.9b01779

Reference yield: 76.0%

SGT1416 (7643-96-1) + 1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine (207857-15-6) → SGT1264

Guidance literature:

SGT₁₄₁₆; 1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine; With triethylamine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/d1md00239b

upstream raw materials:

N-[4-(4-fluoro-phenyl)-4-oxo-butyl]-phthalimide

C₁₀H₁₀FN₃O