N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide

Base Information

Chemical Name:N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide
CAS No.:1262845-70-4
Molecular Formula:C₂₄H₂₈N₄O₂
Molecular Weight:404.512
Hs Code.:

Synonyms:N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide

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Chemical Property of N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide

Chemical Property:

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Technology Process of N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide

There total 5 articles about N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1262847-47-1
3-[5-(4-bromophenyl)isoxazol-3-yl]-N-isopropylbenzamide

: 1262845-70-4
N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; for 18h; Sealed; Heating;

Reference yield:

: 52178-50-4
Methyl 3-formylbenzoate

: 1262845-70-4
N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide; water / ethanol / 3 h / Cooling with ice

1.2: pH 2 - 3

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / Cooling with ice; Heating

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / Sealed; Heating

With N-chloro-succinimide; hydroxylamine hydrochloride; water; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium diacetate; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 596095-27-1
3-((hydroxyimino)methyl)benzoic acid

: 1262845-70-4
N-isopropyl-3-{5-[4-(4-methylpiperazin-1-yl)phenyl]isoxazol-3-yl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / Cooling with ice; Heating

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / Sealed; Heating

With N-chloro-succinimide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; toluene;