6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid

Base Information

Chemical Name:6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid
CAS No.:1093631-58-3
Molecular Formula:C₃₀H₂₇Cl₂NO₄
Molecular Weight:536.455
Hs Code.:

Synonyms:6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid

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Chemical Property of 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid

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Technology Process of 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid

There total 5 articles about 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1093631-97-0
methyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylate

: 1093631-58-3
6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid

Guidance literature:: methyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 24h;

With sodium hydrogen sulfate; In 1,4-dioxane; water;

Reference yield:

: 80859-00-3
6-hydroxy-1,2,3,4-tetrahydro-[1]naphthoic acid

: 1093631-58-3
6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 72 h / Reflux

2: pyridine / dichloromethane / 1.5 h / 0 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 80 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 20 °C

5: lithium hydroxide / 1,4-dioxane / 24 h / 20 °C

With pyridine; thionyl chloride; di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 3: Suzuki Coupling / 4: Mitsunobu reaction;

Reference yield:

: 105207-30-5
6-hydroxy-1,2,3,4-tetrahydro-[1]naphthoic acid methyl ester

: 1093631-58-3
6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 1.5 h / 0 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 80 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 20 °C

4: lithium hydroxide / 1,4-dioxane / 24 h / 20 °C

With pyridine; di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; 2: Suzuki Coupling / 3: Mitsunobu reaction;