4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl)

Base Information

Chemical Name:4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl)
CAS No.:1407830-19-6
Molecular Formula:C₂₂H₁₇ClN₆O₂
Molecular Weight:432.869
Hs Code.:

Synonyms:4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl)

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Chemical Property of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl)

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Technology Process of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl)

There total 9 articles about 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1407833-76-4
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(methoxycarbonyl)pyrimidin-2-yl)-6-(4-chloro-phenyl)

: 1407830-19-6
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl)

Guidance literature:: 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(methoxycarbonyl)pyrimidin-2-yl)-6-(4-chloro-phenyl); With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1407830-19-6
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / tetrahydrofuran / 4 h / 100 °C

2.1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

3.1: sodium / methanol / 0 - 20 °C

4.1: Lawessons reagent / tetrahydrofuran / 80 °C

5.1: butan-1-ol / 130 °C

6.1: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C

7.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 0.25 h / 110 °C / 12901.3 Torr / Microwave irradiation

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

9.1: lithium hydroxide / water; tetrahydrofuran / 1 h / 20 °C

9.2: pH 1

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; potassium acetate; sodium; iron; potassium carbonate; ammonium chloride; caesium carbonate; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; butan-1-ol;

Reference yield:

: 1407833-72-0
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(4-chloro-phenyl)

: 1407830-19-6
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1-methyl-8-(5-(carboxy)pyrimidin-2-yl)-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

2.1: lithium hydroxide / water; tetrahydrofuran / 1 h / 20 °C

2.2: pH 1

With potassium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;