5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

Base Information

Chemical Name:5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine
CAS No.:1610610-23-5
Molecular Formula:C₂₁H₁₄F₄N₂O
Molecular Weight:386.349
Hs Code.:

Synonyms:5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

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Chemical Property of 5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

Chemical Property:

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Technology Process of 5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

There total 6 articles about 5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-41-5
4-Fluorophenol

: 1610612-12-8
5-(bromomethyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

: 1610610-23-5
5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

Guidance literature:: With caesium carbonate; In acetone; at 20 ℃; for 1h;

Reference yield:

: 1610611-83-0
3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid

: 1610610-23-5
5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 50 °C

2: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C

3: phosphorus tribromide / dichloromethane / 2 h / 20 °C

4: caesium carbonate / acetone / 1 h / 20 °C

With thionyl chloride; phosphorus tribromide; diisobutylaluminium hydride; caesium carbonate; In dichloromethane; acetone; toluene;

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1610610-23-5
5-((4-fluorophenoxy)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / N,N-dimethyl-formamide / 40 °C

1.2: 100 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 °C

3.1: phosphorus tribromide / dichloromethane / 2 h / 20 °C

4.1: caesium carbonate / acetone / 1 h / 20 °C

With phosphorus tribromide; diisobutylaluminium hydride; caesium carbonate; O-(2,4-dinitrophenyl)hydroxylamine; In dichloromethane; N,N-dimethyl-formamide; acetone; toluene;