(4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid

Base Information

Chemical Name:(4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid
CAS No.:917023-90-6
Molecular Formula:C₃₆H₄₂O₃
Molecular Weight:522.728
Hs Code.:

Synonyms:(4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid

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Chemical Property of (4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid

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Technology Process of (4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid

There total 9 articles about (4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: C₄₀H₅₂O₃Si

: 917023-90-6
(4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid

Guidance literature:: C₄₀H₅₂O₃Si; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 100 ℃; for 0.0833333h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 865235-91-2
4-[1-ethyl-1-(4-ethynyl-3-methylphenyl)-propyl]-2-methylphenol

: 917023-90-6
(4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran; dichloromethane / 0.17 h / 0 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4.17 h / 100 °C

4.1: pyridine / dichloromethane / 1.5 h / 0 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.12 h / 140 °C / Irradiation

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 100 °C

With pyridine; potassium phosphate; n-butyllithium; tetrabutyl ammonium fluoride; potassium acetate; sodium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 865235-89-8
trifluoromethanesulfonic acid 4-[1-ethyl-1-(4-hydroxy-3-methylphenyl)-propyl]-2-methylphenyl ester

: 917023-90-6
(4'-{1-ethyl-1-[4-(1-hydroxy-cycloheptylethynyl)-3-methyl-phenyl]-propyl}-2'-methylbiphenyl-4-yl)-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 110 °C

1.2: pH 7

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 0 °C

3.2: 2 h / 0 - 20 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran; dichloromethane / 0.17 h / 0 °C

5.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4.17 h / 100 °C

6.1: pyridine / dichloromethane / 1.5 h / 0 °C

7.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.12 h / 140 °C / Irradiation

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 100 °C

With pyridine; potassium phosphate; n-butyllithium; tetrabutyl ammonium fluoride; potassium acetate; sodium hexamethyldisilazane; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;