8-EPI PGF1ALPHA

Base Information

Chemical Name:8-EPI PGF1ALPHA
CAS No.:26771-96-0
Molecular Formula:C₂₀H₃₆O₅
Molecular Weight:356.503
Hs Code.:
Mol file:26771-96-0.mol

Synonyms:Cyclopentaneheptanoicacid, 3,5-dihydroxy-2-(3-hydroxy-1-octenyl)-, stereoisomer (8CI); 8-Epi-PGF1a; 8-Isoprostaglandin F1a

Suppliers and Price of 8-EPI PGF1ALPHA

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
8-iso Prostaglandin F1α ≥99%
1mg
$ 84.00

Cayman Chemical
8-iso Prostaglandin F1α ≥99%
10mg
$ 672.00

Cayman Chemical
8-iso Prostaglandin F1α ≥99%
5mg
$ 378.00

American Custom Chemicals Corporation
9ALPHA,11ALPHA,15S-TRIHYDROXY-(8BETA)-PROST-13E-EN-1-OIC-ACID 99.00%
1MG
$ 208.95

American Custom Chemicals Corporation
9ALPHA,11ALPHA,15S-TRIHYDROXY-(8BETA)-PROST-13E-EN-1-OIC-ACID 99.00%
10MG
$ 1443.75

AK Scientific
8-EPIPGFalpha
10mg
$ 1007.00

Total 3 raw suppliers

Chemical Property of 8-EPI PGF1ALPHA

Chemical Property:

Boiling Point:526.5±50.0 °C(Predicted)
PKA:4.78±0.10(Predicted)
PSA：97.99000
Density:1.136±0.06 g/cm3(Predicted)
LogP:3.26690

Purity/Quality:

97% ^*data from raw suppliers

8-iso Prostaglandin F1α ≥99% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 8-EPI PGF1ALPHA

There total 41 articles about 8-EPI PGF1ALPHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 71120-99-5,71121-00-1,72120-47-9
2β-<(1E)-3-<(tert-butyldimethylsilyl)oxy>oct-1-enyl>-3α-(6-carboxyhexyl)-1α,4α-dihydroxycyclopentanone

: 745-62-0,3613-66-9,10164-73-5,17066-90-9,20348-60-1,21562-54-9,26771-95-9,26771-96-0,34388-84-6,34388-86-8,34388-87-9,34388-89-1,34402-61-4,34437-28-0,37785-86-7,37818-61-4,42048-97-5,42587-03-1,42607-55-6,42607-56-7,54422-22-9,54422-23-0,55528-78-4,57759-92-9,57759-93-0,61375-87-9,61557-40-2,62860-86-0,62960-89-8
(+/-)-prostaglandin F1α

Guidance literature:: With hydrogen fluoride; In water; acetonitrile; for 1h; Ambient temperature;
DOI:10.1021/jo00231a014

Reference yield:

: 78823-20-8
trans-4-<(1E)-3-<(tert-butyldimethylsilyl)oxy>oct-1-enyl>-2,3-epoxycyclopentanone

: 745-62-0,3613-66-9,10164-73-5,17066-90-9,20348-60-1,21562-54-9,26771-95-9,26771-96-0,34388-84-6,34388-86-8,34388-87-9,34388-89-1,34402-61-4,34437-28-0,37785-86-7,37818-61-4,42048-97-5,42587-03-1,42607-55-6,42607-56-7,54422-22-9,54422-23-0,55528-78-4,57759-92-9,57759-93-0,61375-87-9,61557-40-2,62860-86-0,62960-89-8
(+/-)-prostaglandin F1α

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to r.t., 6 h

2: 1.) CuCN / 1.) diethyl ether, -40 deg C, 1.5 h, 2.) ether, from -78 deg C to -10 deg C, overnight

3: KF, pH 7 phosphate buffer / ethanol / 3 h / Ambient temperature

4: 84 percent / L-selectride / tetrahydrofuran / 6 h / Ambient temperature

5: 75 percent / O₂ / PtO₂ / acetone; H₂O / 4 h / 40 °C

6: 90 percent / 47-52percent aq. HF / acetonitrile; H₂O / 1 h / Ambient temperature

With potassium fluoride; pH 7 phosphate buffer; hydrogen fluoride; oxygen; L-Selectride; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; acetone; acetonitrile;
DOI:10.1021/jo00231a014

Reference yield:

: 93566-56-4,93711-56-9,110548-21-5
trans-4,5-epoxy-3-<(1E)-3-<(tert-butyldimethylsilyl)oxy>oct-1-enyl>-1-<(triethylsilyl)oxy>cyclopentene

: 745-62-0,3613-66-9,10164-73-5,17066-90-9,20348-60-1,21562-54-9,26771-95-9,26771-96-0,34388-84-6,34388-86-8,34388-87-9,34388-89-1,34402-61-4,34437-28-0,37785-86-7,37818-61-4,42048-97-5,42587-03-1,42607-55-6,42607-56-7,54422-22-9,54422-23-0,55528-78-4,57759-92-9,57759-93-0,61375-87-9,61557-40-2,62860-86-0,62960-89-8
(+/-)-prostaglandin F1α

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) CuCN / 1.) diethyl ether, -40 deg C, 1.5 h, 2.) ether, from -78 deg C to -10 deg C, overnight

2: KF, pH 7 phosphate buffer / ethanol / 3 h / Ambient temperature

3: 84 percent / L-selectride / tetrahydrofuran / 6 h / Ambient temperature

4: 75 percent / O₂ / PtO₂ / acetone; H₂O / 4 h / 40 °C

5: 90 percent / 47-52percent aq. HF / acetonitrile; H₂O / 1 h / Ambient temperature

With potassium fluoride; pH 7 phosphate buffer; hydrogen fluoride; oxygen; L-Selectride; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; acetone; acetonitrile;
DOI:10.1021/jo00231a014