t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate

Base Information

• Chemical Name: t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate
• CAS No.: 87238-38-8
• Molecular Formula: C₃₄H₄₂N₂O₁₀
• Molecular Weight: 638.715
• Mol file: 87238-38-8.mol

Synonyms:t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate

Chemical Property of t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate

There total 1 articles about t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl 4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrole-2-carboxylate (70988-56-6) + 2-benzoyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methyl-5-(acetoxymethyl)pyrrole (51671-81-9) → t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate (87238-38-8)

Guidance literature:

With sodium tetrahydroborate; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1.)CH₂Cl₂, MeOH, 3 h 2.)MeOH;

DOI:10.1016/S0040-4020(01)88706-8

Reference yield: 72.0%

t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate (87238-38-8) → 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'methyl-2,2'-methylenedipyrrole-5-carboxylic acid (87238-39-9)

Guidance literature:

With boron trifluoride diethyl etherate; In nitromethane; at -15 ℃; for 2h;

DOI:10.1016/S0040-4020(01)88706-8

Reference yield:

t-butyl 5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'-methyl-2,2'-methylenedipyrrole-5-carboxylate (87238-38-8) → 3-(2-Methoxycarbonyl-ethyl)-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methyl-1H-pyrrole-2-carboxylic acid benzyl ester (87238-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / BF₃-etherate / nitromethane / 2 h / -15 °C

2: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)CH₂Cl₂, MeOH room temp. 15 h 2.)CH₂Cl₂, MeOH

With sodium tetrahydroborate; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In nitromethane;

DOI:10.1016/S0040-4020(01)88706-8

upstream raw materials:

t-butyl 4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrole-2-carboxylate

2-benzoyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methyl-5-(acetoxymethyl)pyrrole

Downstream raw materials:

5'-benzyloxycarbonyl-3,4'-di-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-3'methyl-2,2'-methylenedipyrrole-5-carboxylic acid

3-(2-Methoxycarbonyl-ethyl)-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

benzyl 5'-formyl-3',4-di-(2-methoxycarbonylethyl)-4'-methoxycarbonylmethyl-3-methyl-2,2'-methylenedipyrrole-5-carboxylate