N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide

Base Information

• Chemical Name: N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide
• CAS No.: 1357009-31-4
• Molecular Formula: C₂₃H₂₀N₄O₃
• Molecular Weight: 400.437
• Mol file: 1357009-31-4.mol

Synonyms:N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide

Chemical Property of N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide

There total 3 articles about N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-ethyl-6-hydrazino-benzo[de]isoquinoline-1,3-dione (51419-16-0) + 1-isocyanato-4-vinylbenzene (2487-96-9) → N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide (1357009-31-4)

Guidance literature:

With pyridine; In tetrahydrofuran; at 28 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jo3019522

Reference yield:

4-bromo-1,8-naphthalenedicarboxylic anhydride (81-86-7) → N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide (1357009-31-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane / 20 h / Reflux

2: hydrazine hydrate / 1,4-dioxane / 18 h / 60 °C

3: pyridine / tetrahydrofuran / 48 h / 28 °C / Inert atmosphere

With pyridine; hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jo3019522

Reference yield:

6-bromo-2-ethyl-1H-benzo[de]isoquinoline-1,3(2H)dione (100874-09-7) → N-ethyl-4-(N-[4-vinylphenyl]hydrazinecarboxamidyl)-1,8-naphthalimide (1357009-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / 1,4-dioxane / 18 h / 60 °C

2: pyridine / tetrahydrofuran / 48 h / 28 °C / Inert atmosphere

With pyridine; hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jo3019522

upstream raw materials:

4-bromo-1,8-naphthalenedicarboxylic anhydride

2-ethyl-6-hydrazino-benzo[de]isoquinoline-1,3-dione

1-isocyanato-4-vinylbenzene

6-bromo-2-ethyl-1H-benzo[de]isoquinoline-1,3(2H)dione