1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol

Base Information

Chemical Name:1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol
CAS No.:548757-17-1
Molecular Formula:C₃₀H₄₂O₄Si
Molecular Weight:494.747
Hs Code.:

Synonyms:1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol

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Chemical Property of 1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol

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Technology Process of 1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol

There total 7 articles about 1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 548757-16-0
(S)-2-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-propionic acid 2-thioxo-2H-pyridin-1-yl ester

: 548757-17-1
1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol

Guidance literature:: With air; thiophenol; antimony tris-benzenethiolate; In diethyl ether; at 20 ℃; for 1.5h;
DOI:10.1021/jo034129d

Reference yield:

: 548757-15-9
(S)-2-((2R,2aR,4aS,7R,8aR)-2-Hydroxymethyl-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl)-propionic acid

: 548757-17-1
1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 173 mg / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.75 h / 20 °C

2: 82 percent / KOH / H₂O; methanol / 1 h / 20 °C

3: oxalyl chloride / dimethylformamide; benzene / 1 h / 20 °C

4: CH₂Cl₂ / 2 h / 20 °C

5: 115 mg / (PHS)3Sb; air / diethyl ether / 1.5 h / 20 °C

With dmap; potassium hydroxide; oxalyl dichloride; air; thiophenol; antimony tris-benzenethiolate; triethylamine; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; benzene; 5: Barton decarboxylation;
DOI:10.1021/jo034129d

Reference yield:

: 548756-89-4
methyl (3R,4R,5R,11S)-2-acetoxy-1,4:3,5-diepoxy-1,2-secoeudesman-13-oate

: 548757-17-1
1-[(2R,2aR,4aS,7R,8aR)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2a,4a-dimethyl-octahydro-1,3-dioxa-cyclobuta[c]inden-7-yl]-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: KOH / H₂O; methanol / 23 h / 40 °C

2: 173 mg / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2.75 h / 20 °C

3: 82 percent / KOH / H₂O; methanol / 1 h / 20 °C

4: oxalyl chloride / dimethylformamide; benzene / 1 h / 20 °C

5: CH₂Cl₂ / 2 h / 20 °C

6: 115 mg / (PHS)3Sb; air / diethyl ether / 1.5 h / 20 °C

With dmap; potassium hydroxide; oxalyl dichloride; air; thiophenol; antimony tris-benzenethiolate; triethylamine; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; benzene; 6: Barton decarboxylation;
DOI:10.1021/jo034129d