N_α-carbobenzyloxy-N_δ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester

Base Information

• Chemical Name: N_α-carbobenzyloxy-N_δ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester
• CAS No.: 403736-52-7
• Molecular Formula: C₃₄H₃₉N₃O₇
• Molecular Weight: 601.7

Synonyms:N_α-carbobenzyloxy-N_δ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester

Chemical Property of N_α-carbobenzyloxy-N_δ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester

Chemical Property:

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Technology Process of N_α-carbobenzyloxy-N_δ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester

There total 1 articles about N_α-carbobenzyloxy-N_δ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

glycine tert-butyl ester hydrochloride (27532-96-3) + Nα-carbobenzyloxy-Nδ-9-fluorenylmethoxycarbonyl-L-ornithine (201048-68-2) → Nα-carbobenzyloxy-Nδ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester (403736-52-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/S0968-0896(01)00228-0

Reference yield: 92.0%

Nα-carbobenzyloxy-Nδ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester (403736-52-7) → Nα-carbobenzyloxy-L-ornithinylglycin tert-butyl ester (403736-56-1)

Guidance literature:

With diethylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/S0968-0896(01)00228-0

Reference yield:

Nα-carbobenzyloxy-Nδ-9-fluorenylmethoxycarbonyl-L-ornithinylglycin tert-butyl ester (403736-52-7) → [(S)-2-Benzyloxycarbonylamino-5-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-pentanoylamino]-acetic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / diethylamine / acetonitrile / 12 h / 20 °C

2: 26 percent / triethylamine; NaI / acetonitrile / 12 h / 90 °C

3: 100 percent / HCl / CH₂Cl₂ / 4 h / 20 °C

With hydrogenchloride; diethylamine; triethylamine; sodium iodide; In dichloromethane; acetonitrile;

DOI:10.1016/S0968-0896(01)00228-0

upstream raw materials:

glycine tert-butyl ester hydrochloride

N_α-carbobenzyloxy-N_δ-9-fluorenylmethoxycarbonyl-L-ornithine

Downstream raw materials:

N_α-carbobenzyloxy-L-ornithinylglycin tert-butyl ester

[2-benzyloxycarbonylamino-5-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-pentanoylamino]-acetic acid tert-butyl ester

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