N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

Base Information

Chemical Name:N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide
CAS No.:1622003-23-9
Molecular Formula:C₁₄H₁₀ClF₃N₄O
Molecular Weight:342.708
Hs Code.:

Synonyms:N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

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Chemical Property of N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

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Technology Process of N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

There total 2 articles about N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: N-(2-aminophenyl)acrylamide trifluoroacetate

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1622003-23-9
N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 60 ℃; for 1h;

Reference yield:

: 139039-23-9
2-acrylamido-1,2-diaminobenzene

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1622003-23-9
N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

Guidance literature:: With potassium carbonate; In tetrahydrofuran;

Reference yield: 50.0%

: 1622003-23-9
N-(2-((2-chloro-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide

: 19406-86-1
3-Amino-4-methyl-benzamide

: 1621999-56-1
3-(4-(2-acrylamidophenylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-4-methylbenzamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-Amyl alcohol; sodium carbonate; DavePhos; In water; at 100 ℃; Time; Temperature; Solvent; Reagent/catalyst; Inert atmosphere;