1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine

Base Information

• Chemical Name: 1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine
• CAS No.: 1359979-07-9
• Molecular Formula: C₂₃H₂₇N₅O₄
• Molecular Weight: 437.498
• Mol file: 1359979-07-9.mol

Synonyms:1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine

Chemical Property of 1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine

There total 4 articles about 1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

C13H15N3O3 (1359979-16-0) + 1-(3,5-dimethoxyphenyl)piperazine (53557-93-0) → 1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine (1359979-07-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 60 ℃; for 27h;

DOI:10.1016/j.bmc.2011.12.026

Reference yield:

2-amino-3-chloro-5-methylquinoxaline (1275494-82-0) → 1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine (1359979-07-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 20 °C

2: pyridine / dichloromethane / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 27 h / 60 °C

With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2011.12.026

Reference yield:

2,3-dichloro-5-methyl-quinoxaline (82463-30-7) → 1-(3,5-dimethoxyphenyl)-4-[(3-methoxy-5-methylquinoxalin-2-yl)aminocarbonyl]piperazine (1359979-07-9)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia / dimethyl sulfoxide

2: tetrahydrofuran / 20 °C

3: pyridine / dichloromethane / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 27 h / 60 °C

With pyridine; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2011.12.026

upstream raw materials:

2,3-dichloro-5-methyl-quinoxaline

2-amino-3-chloro-5-methylquinoxaline

C₁₃H₁₅N₃O₃

1-(3,5-dimethoxyphenyl)piperazine