7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester

Base Information

Chemical Name:7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester
CAS No.:125442-91-3
Molecular Formula:C₂₂H₂₄Cl₂O₅
Molecular Weight:439.336
Hs Code.:

Synonyms:7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester

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Chemical Property of 7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester

Chemical Property:

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Technology Process of 7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester

There total 6 articles about 7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125442-88-8
malonaldehyde triethyl orthoester

: 125442-90-2
4-(2-Benzyloxy-4,6-dichloro-phenyl)-butan-2-one

: 125442-91-3
7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester

Guidance literature:: With oxonium; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(00)88466-X

Reference yield:

: 121507-32-2
cyanoacetic acid triethyl orthoester

: 125442-91-3
7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / DIBAL / toluene / -78 °C

2: 80 percent Chromat_. / 1.) LDA; 2.) H₃O⁽¹⁺⁾ / tetrahydrofuran / -78 °C

With oxonium; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(00)88466-X

Reference yield:

: 125442-89-9
1-Benzyloxy-2-bromomethyl-3,5-dichloro-benzene

: 125442-91-3
7-(2-Benzyloxy-4,6-dichloro-phenyl)-3-hydroxy-5-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / LDA / tetrahydrofuran / -78 °C

2: 83 percent / DIBAL / toluene / -78 °C

3: 98 percent / H₃O⁽¹⁺⁾ / tetrahydrofuran / 0 °C

4: 79 percent / Jones reagent

5: 80 percent Chromat_. / 1.) LDA; 2.) H₃O⁽¹⁺⁾ / tetrahydrofuran / -78 °C

With jones reagent; oxonium; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(00)88466-X