(2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide

Base Information

Chemical Name:(2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide
CAS No.:213695-89-7
Molecular Formula:C₃₃H₄₆N₄O₄S₂Si
Molecular Weight:654.97
Hs Code.:

Synonyms:(2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide

Suppliers and Price of (2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide

There total 4 articles about (2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 213695-88-6
(2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanamide

: 213695-89-7
(2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide

Guidance literature:: With Lawessons reagent; In 1,2-dimethoxyethane; for 12h; Ambient temperature;
DOI:10.3987/com-98-8152

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 213695-89-7
(2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / imidazole / dimethylformamide / 24.5 h / 0 - 20 °C

2: H₂ / Pd/C / ethanol / 4 h / 20 °C

3: 97 percent / diphenoxyphosphinoyl azide; Et₃N / dimethylformamide / 0 - 20 °C

4: 56 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 6 h / 20 °C

With Lawessons reagent; 1H-imidazole; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; 1: silylation / 2: Hydrogenolysis / 3: Acylation / 4: Substitution;
DOI:10.1246/bcsj.72.2483

Reference yield:

: 213695-83-1
(2S,3R)-2-benzyloxycarbonylamino-3-(t-butyldiphenylsiloxy)butanamide

: 213695-89-7
(2S,3R)-2-{2-[(R)-1-(t-butoxycarbonylamino)-2-methylpropyl]thiazol-4-ylcarbonylamino}-3-(t-butyldiphenylsiloxy)butanethioamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol / 4 h / 20 °C

2: 97 percent / diphenoxyphosphinoyl azide; Et₃N / dimethylformamide / 0 - 20 °C

3: 56 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 6 h / 20 °C

With Lawessons reagent; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Acylation / 3: Substitution;
DOI:10.1246/bcsj.72.2483