tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester

Base Information

• Chemical Name: tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester
• CAS No.: 151012-05-4
• Molecular Formula: C₄₁H₅₃N₅O₉
• Molecular Weight: 759.9
• Mol file: 151012-05-4.mol

Synonyms:tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester

Chemical Property of tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester

There total 2 articles about tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginine (14611-34-8) → tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester (151012-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0.33 h

2: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

With triethylamine; In dichloromethane;

DOI:10.1021/jm950803a

Reference yield:

N-BOC-N-methylnorleucine (117903-25-0) → tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester (151012-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) conc. H₂SO₄ / 1.) dioxane, 15 min, 2.) dioxane, 5 h

2: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

With sulfuric acid; triethylamine; In dichloromethane;

DOI:10.1021/jm950803a

Reference yield: 89.0%

tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine tert-butyl ester (151012-05-4) → Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine (151012-06-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.666667h;

DOI:10.1021/jm950803a

upstream raw materials:

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginine

N-BOC-N-methylnorleucine

Downstream raw materials:

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methylnorleucine

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl ester

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginyl-N-methyl-L-norleucyl-L-aspartic acid β-cyclohexyl-α-tert-butyl ester