5-(2-CYCLOHEXYL-ETHYL)-[1,3,4]THIADIAZOL-2-YLAMINE

Base Information

• Chemical Name: 5-(2-CYCLOHEXYL-ETHYL)-[1,3,4]THIADIAZOL-2-YLAMINE
• CAS No.: 118314-04-8
• Molecular Formula: C₁₀H₁₇N₃S
• Molecular Weight: 211.331
• Mol file: 118314-04-8.mol

Synonyms:5-(2-cyclohexylethyl)-1,3,4-thiadiazol-2-amine

Chemical Property of 5-(2-CYCLOHEXYL-ETHYL)-[1,3,4]THIADIAZOL-2-YLAMINE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-(2-Cyclohexylethyl)-1,3,4-thiadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-(2-Cyclohexylethyl)-1,3,4-thiadiazol-2-amine is a reagent used for the synthesis of 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one, an anti-allergic agent and mast cell stabilizer.

Technology Process of 5-(2-CYCLOHEXYL-ETHYL)-[1,3,4]THIADIAZOL-2-YLAMINE

There total 4 articles about 5-(2-CYCLOHEXYL-ETHYL)-[1,3,4]THIADIAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-cyclohexylpropionitrile (41010-09-7) + thiosemicarbazide (79-19-6) → 5-(2-cyclohexylethyl)-1,3,4-thiadiazol-2-amine (118314-04-8)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1248/cpb.40.2391

Reference yield:

3-cyclohexane-2-propenenitrile (6050-00-6) → 5-(2-cyclohexylethyl)-1,3,4-thiadiazol-2-amine (118314-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.1 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

2: 83 percent / CF₃COOH

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1248/cpb.40.2391

Reference yield:

cyclohexanecarbaldehyde (2043-61-0) → 5-(2-cyclohexylethyl)-1,3,4-thiadiazol-2-amine (118314-04-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 94.1 percent / 40percent aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 94.1 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

3: 83 percent / CF₃COOH

With sodium hydroxide; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1248/cpb.40.2391

upstream raw materials:

3-cyclohexylpropionitrile

thiosemicarbazide

3-cyclohexane-2-propenenitrile

cyclohexanecarbaldehyde

Downstream raw materials:

7-Hydroxy-2-octyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

2-(2-cyclohexylethyl)-7-hydroxy-5H-1,3,4-thiadiazolo<3,2-a>pyrimidin-5-one

2-Chloro-N-[5-(2-cyclohexyl-ethyl)-[1,3,4]thiadiazol-2-yl]-acetamide

7-chloro-2-(2-cyclohexylethyl)-6-nitro-5H-1,3,4-thiadiazolo<3,2-a>pyrimidin-5-one