3-{4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl}pyridine-2-carbonitrile hydrochloride

Base Information

• Chemical Name: 3-{4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl}pyridine-2-carbonitrile hydrochloride
• CAS No.: 1055304-96-5
• Molecular Formula: C₁₈H₁₆N₄O₂S*ClH
• Molecular Weight: 388.878
• Mol file: 1055304-96-5.mol

Synonyms:3-{4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl}pyridine-2-carbonitrile hydrochloride

Chemical Property of 3-{4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl}pyridine-2-carbonitrile hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl}pyridine-2-carbonitrile hydrochloride

There total 2 articles about 3-{4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl}pyridine-2-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

tert-butyl {[5-(2-cyanopyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate (1055306-44-9) → 3-{4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl}pyridine-2-carbonitrile hydrochloride (1055304-96-5)

Guidance literature:

With hydrogenchloride; In methanol; ethanol; water; ethyl acetate; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2017.04.014

Reference yield:

tert-butyl {[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate (1055306-43-8) → 3-{4-[(methylamino)methyl]-1-(phenylsulfonyl)-1H-pyrrol-2-yl}pyridine-2-carbonitrile hydrochloride (1055304-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

2: hydrogenchloride / water; methanol; ethanol; ethyl acetate / 4 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2017.04.014

upstream raw materials:

tert-butyl {[5-(2-cyanopyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

tert-butyl {[5-(2-chloropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate