isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester
• CAS No.: 256411-77-5
• Molecular Formula: C₂₅H₂₇F₃N₂O₆
• Molecular Weight: 508.494

Synonyms:isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester

Chemical Property of isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester

Chemical Property:

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Technology Process of isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester

There total 4 articles about isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 2,2,2-trifluoro-N-[7-(3-isobutylamino-propionyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-acetamide → isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester (256411-77-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0960-894X(99)00555-7

Reference yield:

6-amino-3,4-benzodioxane (22013-33-8) → isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester (256411-77-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 88 percent / AlCl₃ / CH₂Cl₂ / 20 °C

3: CH₂Cl₂ / 20 °C

4: Et₃N / CH₂Cl₂ / 20 °C

With aluminium trichloride; triethylamine; In dichloromethane; 1: Acylation / 2: Elimination / 3: Michael addition / 4: Benzyloxycarbonylation;

DOI:10.1016/S0960-894X(99)00555-7

Reference yield:

N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2,2,2-trifluoro-acetamide (256411-48-0) → isobutyl-{3-oxo-3-[7-(2,2,2-trifluoro-acetylamino)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-propyl}-carbamic acid benzyl ester (256411-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / AlCl₃ / CH₂Cl₂ / 20 °C

2: CH₂Cl₂ / 20 °C

3: Et₃N / CH₂Cl₂ / 20 °C

With aluminium trichloride; triethylamine; In dichloromethane; 1: Elimination / 2: Michael addition / 3: Benzyloxycarbonylation;

DOI:10.1016/S0960-894X(99)00555-7

upstream raw materials:

benzyl chloroformate

6-amino-3,4-benzodioxane

N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2,2,2-trifluoro-acetamide

N-(7-acryloyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-2,2,2-trifluoro-acetamide

Downstream raw materials:

[3-(7-amino-2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-oxo-propyl]-isobutyl-carbamic acid benzyl ester

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