1-(2,6-Difluorophenyl)piperazine

Base Information

Chemical Name:1-(2,6-Difluorophenyl)piperazine
CAS No.:255893-56-2
Molecular Formula:C₁₀H₁₂F₂N₂
Molecular Weight:198.215
Hs Code.:
DSSTox Substance ID:DTXSID501301214
Nikkaji Number:J3.226.006C

Synonyms:1-(2,6-difluorophenyl)piperazine;255893-56-2;SCHEMBL746343;YWTWDUFMPFRGJQ-UHFFFAOYSA-N;4-(2,6-Difluorophenyl)piperazine;DTXSID501301214;GS1314;AKOS010081867;EN300-141708

Suppliers and Price of 1-(2,6-Difluorophenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-(2,6-Difluorophenyl)piperazine

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:198.09685472
Heavy Atom Count:14
Complexity:173

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1)C2=C(C=CC=C2F)F

Technology Process of 1-(2,6-Difluorophenyl)piperazine

There total 3 articles about 1-(2,6-Difluorophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 5509-65-9
2,6-difluoroaniline

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 255893-56-2
1-(2,6-difluorophenyl)piperazine

Guidance literature:: 2,6-difluoroaniline; bis-(2-chloroethyl)amine hydrochloride; In butan-1-ol; for 48h; Heating;

With sodium carbonate; In butan-1-ol; for 24h; Heating;
DOI:10.1248/cpb.50.453

Reference yield:

: tert-butyl 4-(2,6-difluorophenyl)piperazine-1-carboxylate

: 255893-56-2
1-(2,6-difluorophenyl)piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 110-85-0
piperazine

: 1489-53-8
1,2,3-trifluorobenzene

: 876379-86-1
1-(2,3-difluorophenyl)piperazine

: 255893-56-2
1-(2,6-difluorophenyl)piperazine

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 190 ℃; for 1h; Overall yield = 73 %; Microwave irradiation; Sealed tube;
DOI:10.1016/j.jfluchem.2012.12.001