2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride

Base Information

Chemical Name:2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride
CAS No.:1047646-20-7
Molecular Formula:C₁₇H₁₄F₂N₂O₂*ClH
Molecular Weight:352.768
Hs Code.:

Synonyms:2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride

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Chemical Property of 2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride

Chemical Property:

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Technology Process of 2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride

There total 3 articles about 2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430058-24-4
C₂₂H₂₂F₂N₂O₄

: 1047646-20-7
2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

Reference yield:

: 845543-57-9
tert-butyl [(1S)-1-(3,5-difluorobenzyl)-2-hydroxyethyl]carbamate

: 1047646-20-7
2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 205445-52-9,669057-06-1
(2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,5-difluorophenyl)propanoic acid

: 1047646-20-7
2-[(2S)-2-amino-3-(3,5-difluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 3 h / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

With hydrogenchloride; borane-THF; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol;