2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile

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Chemical Name:2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile
CAS No.:1357358-50-9
Molecular Formula:C₂₆H₁₉N₅S
Molecular Weight:433.536
Hs Code.:

Synonyms:2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile

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Chemical Property of 2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile

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Technology Process of 2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile

There total 3 articles about 2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1357358-49-6
2-[5-(N,N-di(p-tolyl)amino)thiophen-2-yl]-pyrimidine-5-carbaldehyde

: 109-77-3
malononitrile

: 1357358-50-9
2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile

Guidance literature:: With aluminum oxide; In toluene; at 70 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c2cc16390j

Reference yield:

: 89331-93-1
2-[N,N-di(p-tolyl)amino]thiophene

: 1357358-50-9
2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 - -35 °C / Inert atmosphere

1.2: 0.5 h / -35 - 20 °C / Inert atmosphere

1.3: 2 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -100 °C / Inert atmosphere

2.2: 0.58 h / -100 °C / Inert atmosphere

3.1: aluminum oxide / toluene / 1 h / 70 °C / Inert atmosphere

With aluminum oxide; n-butyllithium; In tetrahydrofuran; toluene; 1.1: Negishi coupling reaction / 1.3: Negishi coupling reaction / 3.1: Knoevenagel condensation;
DOI:10.1039/c2cc16390j

Reference yield:

: 1357358-48-5
[5-(5-bromo-pyrimidin-2-yl)-thiophen-2-yl]-N,N-di(p-tolyl)amine

: 1357358-50-9
2-{[2-(5-N,N-di(p-tolyl)aminothiophen-2-yl)-pyrimidin-5-yl]methylene}malononitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -100 °C / Inert atmosphere

1.2: 0.58 h / -100 °C / Inert atmosphere

2.1: aluminum oxide / toluene / 1 h / 70 °C / Inert atmosphere

With aluminum oxide; n-butyllithium; In tetrahydrofuran; toluene; 2.1: Knoevenagel condensation;
DOI:10.1039/c2cc16390j