N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide

Base Information

Chemical Name:N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide
CAS No.:63232-06-4
Molecular Formula:C₂₇H₁₉ClN₄O₂
Molecular Weight:466.926
Hs Code.:

<i>N</i>-[2-(8-chloro-6-phenyl-4<i>H</i>-benzo[<i>f</i>]imidazo[1,5-<i>a</i>][1,4]diazepin-1-yl)-ethyl]-phthalimide

Synonyms:N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide

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Chemical Property of N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide

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Technology Process of N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide

There total 10 articles about N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63200-66-8
2-[2-(2-Bromomethyl-[1,3]dioxolan-2-yl)-ethyl]-isoindole-1,3-dione

: 63232-06-4
N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / NaN₃ / dimethylsulfoxide / 18 h / 120 °C / Heating

2: 12.7 g / H₂ / 10percent Pd/C / ethyl acetate / 2 h

3: 2.) 97percent H₂SO₄ / 1.) EtOH, 60 deg C 2.) RT

4: TiCl₄ / 1,2-dimethoxy-ethane / 1.) 0 deg C, 2.) reflux, 18 h

With sodium azide; sulfuric acid; hydrogen; titanium tetrachloride; palladium on activated charcoal; In 1,2-dimethoxyethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00321a010

Reference yield:

: 63200-65-7
N-<2-<2-(azidomethyl)-1,3-dioxolan-2-yl>ethyl>phthalimide

: 63232-06-4
N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide

Guidance literature:: Multi-step reaction with 3 steps

1: 12.7 g / H₂ / 10percent Pd/C / ethyl acetate / 2 h

2: 2.) 97percent H₂SO₄ / 1.) EtOH, 60 deg C 2.) RT

3: TiCl₄ / 1,2-dimethoxy-ethane / 1.) 0 deg C, 2.) reflux, 18 h

With sulfuric acid; hydrogen; titanium tetrachloride; palladium on activated charcoal; In 1,2-dimethoxyethane; ethyl acetate;
DOI:10.1021/jo00321a010

Reference yield:

: 51132-00-4
2-(4-bromo-3-oxobutyl)isoindoline-1,3-dione

: 63232-06-4
N-[2-(8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-1-yl)-ethyl]-phthalimide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / conc. H₂SO₄ / benzene / 5 h / Heating

2: 64 percent / NaN₃ / dimethylsulfoxide / 18 h / 120 °C / Heating

3: 12.7 g / H₂ / 10percent Pd/C / ethyl acetate / 2 h

4: 2.) 97percent H₂SO₄ / 1.) EtOH, 60 deg C 2.) RT

5: TiCl₄ / 1,2-dimethoxy-ethane / 1.) 0 deg C, 2.) reflux, 18 h

With sodium azide; sulfuric acid; hydrogen; titanium tetrachloride; palladium on activated charcoal; In 1,2-dimethoxyethane; dimethyl sulfoxide; ethyl acetate; benzene;
DOI:10.1021/jo00321a010