p-neopentoxyphenylacetylene

Base Information

• Chemical Name: p-neopentoxyphenylacetylene
• CAS No.: 371197-25-0
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.269
• Mol file: 371197-25-0.mol

Synonyms:p-neopentoxyphenylacetylene

Chemical Property of p-neopentoxyphenylacetylene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-neopentoxyphenylacetylene

There total 4 articles about p-neopentoxyphenylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-trimethylsilyl-2-(p-neopentoxyphenyl)acetylene (371197-24-9) → p-neopentoxyphenylacetylene (371197-25-0)

Guidance literature:

With sodium hydroxide; In methanol; water; for 0.25h;

DOI:10.1139/v00-186

Reference yield:

2,2-dimethyl-propanol-1 (75-84-3) → p-neopentoxyphenylacetylene (371197-25-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / pyridine / 20 °C

2: 82 percent / potassium hydroxide; hexamethylphosphoramide / 72 h / 100 °C

3: 88 percent / copper(I) iodide; triethylamine; Pd(PPh₃)2Cl₂ / 20 °C

4: 95 percent / sodium hydroxide / methanol; H₂O / 0.25 h

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; sodium hydroxide; copper(l) iodide; triethylamine; In methanol; water;

DOI:10.1139/v00-186

Reference yield:

neopentyl tosylate (2346-07-8) → p-neopentoxyphenylacetylene (371197-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / potassium hydroxide; hexamethylphosphoramide / 72 h / 100 °C

2: 88 percent / copper(I) iodide; triethylamine; Pd(PPh₃)2Cl₂ / 20 °C

3: 95 percent / sodium hydroxide / methanol; H₂O / 0.25 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; sodium hydroxide; copper(l) iodide; triethylamine; In methanol; water;

DOI:10.1139/v00-186

upstream raw materials:

1-trimethylsilyl-2-(p-neopentoxyphenyl)acetylene

2,2-dimethyl-propanol-1

neopentyl tosylate

p-iodo(neopentoxy)benzene

Downstream raw materials:

4,5-di[4-(p-neopentoxyphenyl)-1,3-butadiynyl]phthalonitrile

1-(trimethylsilyl)-4-(p-neopentoxyphenyl)-1,3-butadiyne

1-(p-neopentoxyphenyl)-1,3-butadiyne

1-iodo-2-(p-neopentoxyphenyl)acetylene