(4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
• CAS No.: 192129-70-7
• Molecular Formula: C₂₃H₃₆N₂O₆
• Molecular Weight: 436.549
• Mol file: 192129-70-7.mol

Synonyms:(4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Chemical Property of (4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 8 articles about (4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (192129-55-8) → (4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (192129-70-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1016/S0957-4166(97)00164-X

Reference yield:

3-<(tert-Butoxycarbonyl)amino>-4-O-(tert-butyldiphenylsilyl)-3-deoxy-3-N,2-O-isopropylidene-D-threose (138319-97-8) → (4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (192129-70-7)

Guidance literature:

Multi-step reaction with 8 steps

1: CH₂Cl₂ / 24 h

2: 1.) CuI / 1.) ether, -30 deg C, 45 min, 2.) ether, -50 deg C

3: 66 percent / H₂ / Raney nickel / ethanol / 4 h / 2280 Torr

4: 2,6-lutidine / CHCl₃ / 0.5 h / -50 °C

5: tetramethylguanidiniumazide / CHCl₃ / 1 h

6: H₂ / 10percent Pd/C / tetrahydrofuran

7: 3N aq. NaOH / dioxane / 0.75 h / 0 °C

8: 88 percent / n-tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C

With 2,6-dimethylpyridine; sodium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; N,N,N′,N′-tetramethylguanidinium azide; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform;

DOI:10.1016/S0957-4166(97)00164-X

Reference yield:

(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-5-((E)-3-oxo-propenyl)-oxazolidine-3-carboxylic acid tert-butyl ester (182962-13-6) → (4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (192129-70-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) CuI / 1.) ether, -30 deg C, 45 min, 2.) ether, -50 deg C

2: 66 percent / H₂ / Raney nickel / ethanol / 4 h / 2280 Torr

3: 2,6-lutidine / CHCl₃ / 0.5 h / -50 °C

4: tetramethylguanidiniumazide / CHCl₃ / 1 h

5: H₂ / 10percent Pd/C / tetrahydrofuran

6: 3N aq. NaOH / dioxane / 0.75 h / 0 °C

7: 88 percent / n-tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C

With 2,6-dimethylpyridine; sodium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; N,N,N′,N′-tetramethylguanidinium azide; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform;

DOI:10.1016/S0957-4166(97)00164-X

upstream raw materials:

(4R,5R)-5-((R)-3-Benzyloxycarbonylamino-1-methyl-propyl)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

3-<(tert-Butoxycarbonyl)amino>-4-O-(tert-butyldiphenylsilyl)-3-deoxy-3-N,2-O-isopropylidene-D-threose

(4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(4R,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-5-((E)-3-oxo-propenyl)-oxazolidine-3-carboxylic acid tert-butyl ester