1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane

Base Information

• Chemical Name: 1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane
• CAS No.: 202586-36-5
• Molecular Formula: C₃₄H₅₁N₅O₆
• Molecular Weight: 625.809

Synonyms:1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane

Chemical Property of 1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane

Chemical Property:

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Technology Process of 1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane

There total 1 articles about 1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methoxycarbonyl-(L)-isoleucine + 1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane (202586-31-0) → 1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane (202586-36-5)

Guidance literature:

With benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane (202586-36-5) → 1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane hydrochloride (202586-37-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol;

upstream raw materials:

1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane

Downstream raw materials:

1-[p-(pyrrolidin-1-yl)phenyl]-4(S)-hydroxy-2-amino-5(S)-[N-(N-methoxycarbonyl-(L)-isoleucyl)amino]-6-phenyl-2-azahexane hydrochloride

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