(3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine

Base Information

Chemical Name:(3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine
CAS No.:1186331-97-4
Molecular Formula:C₃₀H₂₉N₇O
Molecular Weight:503.607
Hs Code.:

Synonyms:(3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine

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Chemical Property of (3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine

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Technology Process of (3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine

There total 10 articles about (3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1186334-39-3
7-(2-chloropyridin-4-yl)-3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

: 6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5
(3R)-quinuclidin-3-amine dihydrochloride

: 1186331-97-4
(3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 170 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1134598-69-8
2-(3-methoxyphenyl)-3-oxo-3-pyridin-4-yl-propionitrile

: 1186331-97-4
(3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 18 h / 80 °C

2: hydrazine hydrate / ethanol / 6.5 h / Reflux

3: acetic acid / 1 h / 120 °C / Microwave irradiation

4: trichlorophosphate / 1 h / Reflux

5: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 170 °C / Microwave irradiation

With hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dimethyl sulfoxide;

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1186331-97-4
(3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol; sodium / 4 h / 45 °C / Reflux

2: trichlorophosphate / 18 h / 80 °C

3: hydrazine hydrate / ethanol / 6.5 h / Reflux

4: acetic acid / 1 h / 120 °C / Microwave irradiation

5: trichlorophosphate / 1 h / Reflux

6: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 170 °C / Microwave irradiation

With ethanol; sodium; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dimethyl sulfoxide;