4-(2-Hydrazinylethyl)morpholine

Base Information

• Chemical Name: 4-(2-Hydrazinylethyl)morpholine
• CAS No.: 2154-24-7
• Molecular Formula: C6H15 N3 O
• Molecular Weight: 145.2
• Hs Code.: 2934999090
• European Community (EC) Number: 827-345-7
• DSSTox Substance ID: DTXSID30388681
• Nikkaji Number: J2.342.243C
• Wikidata: Q82183796
• Mol file: 2154-24-7.mol

Synonyms:4-(2-hydrazinylethyl)morpholine;2154-24-7;2-morpholin-4-ylethylhydrazine;(2-morpholin-4-yl-ethyl)-hydrazine;1-(2-morpholinoethyl)hydrazine;Morpholine, 4-(2-hydrazinoethyl)-;SCHEMBL696834;4-(2-hydrazinoethyl)morpholine;2-(n-morpholinyl)ethylhydrazine;DTXSID30388681;MEXIDHXEOHJKLS-UHFFFAOYSA-N;CAA15424;MFCD07786279;AKOS000133622;FS-4704;4-(2-hydrazinoethyl)morpholine, AldrichCPR;CS-0216748;FT-0684464;EN300-57958;F52067;J-513305;F2169-0396

Chemical Property of 4-(2-Hydrazinylethyl)morpholine

Chemical Property:

• Boiling Point: 125 °C(Press: 12 Torr)
• PKA: 8.19±0.70(Predicted)
• PSA: 50.52000
• Density: 1.050 g/cm3
• LogP: -0.18900
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 145.121512110
• Heavy Atom Count: 10
• Complexity: 83.1

Purity/Quality:

98% ^*data from raw suppliers

4-(2-Hydrazinylethyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CCNN

Technology Process of 4-(2-Hydrazinylethyl)morpholine

There total 4 articles about 4-(2-Hydrazinylethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-(2-chloroethyl)morpholine hydrochride (3647-69-6) → N-(2-hydrazinoethyl)morpholine (2154-24-7)

Guidance literature:

4-(2-chloroethyl)morpholine hydrochride; With potassium carbonate; In water;

With hydrazine hydrate; for 1h; Reflux;

DOI:10.3987/COM-08-11371

Reference yield:

N-(2-bromoethyl)morpholine (89583-07-3) → N-(2-hydrazinoethyl)morpholine (2154-24-7)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

DOI:10.1021/jm00117a010

Reference yield:

N-(2-chlorethyl)morpholine (3240-94-6) → N-(2-hydrazinoethyl)morpholine (2154-24-7)

Guidance literature:

With hydrazine;

upstream raw materials:

N-(2-chlorethyl)morpholine

N-(2-bromoethyl)morpholine

4-(2-chloroethyl)morpholine hydrochride

Downstream raw materials:

2-(2-morpholin-4-yl-ethyl)-4-phenyl-2H-phthalazin-1-one

2-(2-morpholin-4-yl-ethyl)-8-phenyl-4,5,6,7-tetrahydro-2H-[1,2]diazocin-3-one

6-(4-bromo-phenyl)-4-methyl-2-(2-morpholin-4-yl-ethyl)-2H-pyridazin-3-one

6-(3-bromo-phenyl)-4-methyl-2-(2-morpholin-4-yl-ethyl)-2H-pyridazin-3-one

Refernces

• 1、 Antonini,Polucci,Cola,Palmieri,Martelli,Bontemps-Gracz. "Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs". . p. 1641 - 1648. Retrieved 2007/10/02.